Formulation of antibacterial hand cream based on chitosan and leaves of putri malu extract (Mimosa pudica L.) / Formulasi hand cream antibakteri berbasis kitosan dan ekstrak daun putri malu (Mimosa pudica L.)

CoronaVirus Disease 2019 is a respiratory disease caused by Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) which is transmitted through the air and droplets of fluid. One of the health protocols recommended by the World Health Organization (WHO) is washing hands. Hand-washing activities have limitations because not all places provide them, so the alternative that has been circulating in the community is hand sanitiser. However, the alcohol content and synthetic antibacterials cause dry and irritated skin. The purpose of this study was to create an antibacterial hand cream from putri malu leaf as a utilization of wild plants. Putri malu leaf extract and chitosan were made in the form of nanoparticles, and then an evaluation of the physical characteristics of the hand cream preparation was carried out in the form of pH, organoleptic, homogeneity, and stability observed for 14 days. The antibacterial activity of putri malu leaf extract and hand cream was tested against S. aureus and E. coli. The particle size obtained was 1529.5 ± 42.5 nm. The results of the physical characteristics obtained were pH 6.15; dark orange, odourless, stable at room temperature, and high homogeneity. Antibacterial testing of putri malu leaf extract against S. aureus produced an inhibition zone of 10.27 mm at a concentration of 25% and antibacterial hand cream produced inhibition zones of 23.18 mm and 12.22 mm with an extract concentration of 10% so both are classified as strong antibacterials that are effective against S. aureus and E. coli bacteria.

CoronaVirus Disease 2019 merupakan penyakit sistem pernapasan yang disebabkan oleh Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) yang ditransmisikan melalui udara dan droplet cairan. Salah satu protokol kesehatan yang dianjurkan oleh World Health Organization (WHO) adalah mencuci tangan. Kegiatan mencuci tangan memiliki keterbatasan karena tidak semua tempat menyediakannya sehingga alternatif yang telah beredar di masyarakat yakni hand sanitizer. Tetapi, kandungan alkohol dan antibakteri sintetik menyebabkan kulit kering dan iritasi. Tujuan penelitian ini untuk menciptakan hand cream antibakteri dari daun putri malu sebagai pemanfaatan tanaman liar. Ekstrak daun putri malu dan kitosan dibuat dalam bentuk nanopartikel, kemudian dilakukan evaluasi karakteristik fisik sediaan hand cream berupa pH, organoleptik, homogenitas, dan stabilitas diamati selama 14 hari. Aktivitas antibakteri ekstrak daun putri malu dan hand cream diuji terhadap S. aureus dan E. coli. Ukuran partikel yang didapat sebesar 1529,5±42,5 nm. Hasil karakteristik fisik yang didapat berupa pH 6,15; berwarna jingga tua, tidak berbau, stabil di suhu ruang, dan tingkat homogenitas tinggi. Pengujian antibakteri ekstrak daun putri malu terhadap S. aureus menghasilkan zona hambat 10,27 mm pada konsentrasi 25% dan antibakteri hand cream menghasilkan zona hambat 23,18 mm dan 12,22 mm dengan konsentrasi ekstrak 10% sehingga keduanya tergolong antibakteri kuat yang efektif terhadap bakteri S. aureus dan E. coli.