Evaluation of analgesic and antidiarrheal activity of Clitoria ternatea Linn. ethanol flower extract / Evaluasi aktivitas analgesik dan antidiare ekstrak etanol bunga telang (Clitoria ternatea Linn.)

The analgesic and antidiarrheal effects of Clitoria ternatea Linn. flower extract were tested in mice. A significant analgesic response (p<0.05) was observed in acetic acid-induced pain models in a dose-dependent manner. The percent protection of analgesic properties was calculated from the reduction of writhing by butterfly pea ethanol extract. The Butterfly pea extract doses at 100, 200, and 400 mg/ kg showed analgesic protection by 76.6% (9.4  ± 3.65), 93.9% (2.4 ± 1.95), and 97.5% (1.0 ± 0.71), respectively. The antidiarrheal properties of Clitoria ternatea Linn. flower extract were assessed using the castor oil-induced diarrhea method. Clitoria ternatea Linn. flower extract delayed the onset of castor oil-induced diarrhea in a dose-dependent manner and reduced the frequency of defecation. There was no significant difference (p>0.05) between the effects of 400 mg/kg of Clitoria ternatea Linn. flower extract and loperamide in protecting mice against castor oil-induced diarrhea. Based on the study results, it is suggested that the Clitoria ternatea Linn. flower extract has strong analgesic and antidiarrheal properties.

Efek analgesik dan antidiare dari ekstrak etanol bunga telang (EBT) telah diujikan pada hewan uji mencit. EBT jika dibandingkan dengan kelompok kontrol pensuspensi secara signifikan (p<0,05) menurunkan jumlah geliat mencit yang diinduksi nyeri dengan menggunakan asam asetat. Persentase proteksi analegesik dihitung dari pengurangan geliat mencit. EBT dosis 100, 200, dan 400 mg/kgBB menunjukkan proteksi analgesik secara berturut-turut sebesar 76,6% (9,4 ± 3,65), 93,9% (2,4 ± 1,95), dan 97,5% (1,0 ± 0,71). Efek antidiare EBT dievaluasi menggunakan model mencit diare yang induksi oleum ricini. Diketahui EBT dapat menunda onset diare yang diakibatkan oleh oleum ricini dan menurunkan frekuensi buang air besar. Tidak ada perbedaan bermakna (p>0,05) antara kelompok yang diberi EBT dosis 400 mg/kgBB dengan kelompok yang diberi loperamide. Dari hasil tersebut dapat disimpulkan bahwa EBT mempunyai aktivitas analgesik dan antidiare.