Study on anti-emetic drug use in lnh patients at one day care room Dr. M Djamil Padang hospital / Kajian penggunaan obat anti emetik pada pasien lnh di ruang one day care RSUP Dr. M Djamil Padang

In the treatment of non-Hodgkin's lymphoma, a combination of chemotherapy drugs (Cyclophospamide, Doxorubicin, Vincristine, and Prednisone) is commonly used. Chemotherapy can lead to side effects such as nausea and vomiting, which can be uncomfortable for patients and may interfere with their treatment. This study aimed to analyze the usage pattern of antiemetics, the compatibility of antiemetics with the emetogenic risk of combination chemotherapy, and the relationship between antiemetic dosage suitability and RINVR scores (Rhodes Index Nausea Vomiting and Retching). The RINVR instrument consists of 8 questions, which evaluates the duration, frequency, amount/volume, and stress related to nausea or vomiting. The study involved 30 patients and data were collected through telephone interviews and patient's medical records. Statistical tests using the independent T test showed mild nausea and vomiting (0-8) for both acute and delayed symptoms against the condition of post-chemotherapy. A normality of RINVR scores was tested and it was determined that the scores were not normally distributed (p<0.05). In bivariate analysis, it was found that the average RINVR scores for both acute and delayed symptoms did not show statistically significant differences (p>0.05). This suggests chemotherapy with emetogenic combination still causes nausea and vomiting even though appropriate antiemetics have been given.

Pada pengobatan Limfoma Non Hodgkin (LNH) digunakan terapi (Siklofospamid, Doksorubisin, Vinkristin, Prednison). Efek samping dari kemoterapi yaitu mual dan muntah yang dapat menggangu pengobatan dan  menyebabkan ketidaknyamanan. Penelitian ini bertujuan melihat pola penggunaan antiemetik, kesesuaian antiemetik dengan resiko ematogenik obat kemoterapi kombinasi dan hubungan kesesuaian dosis antiemetik dengan skor RINVR (Rhodes Index Nausea Vomiting and Retching). Instrument RINVR terdiri dari 8 pertanyaan terkait durasi, frekuensi, jumlah/volume, stress akibat mual/muntah. Responden pada penelitian ini berjumlah 30 orang. Data diperoleh dari hasil wawancara via telepon dan rekam medis pasien. Dari hasil Uji statistik menggunakan uji T independen menunjukkan skor RINVR akut maupun delayed terhadap kondisi responden pasca kemoterapi dalam keadaan mual muntah ringan (0-8). Setelah dilakukan uji normalitas diketahui bahwa semua skor RINVR pasien tidak terdistribusi normal (p<0,05). Pada analisa bivariat, semua hasil analisa secara statistik didapatkan nilai p value >0,05 baik perbandingan rata rata skor RINVR akut maupun delayed. Ini menunjukkan bahwa kemoterapi dengan ematogenik kombinasi masih menyebabkan mual muntah meskipun sudah diberikan antiemetik yang sesuai.