Anatomical Therapeutic Chemical / Define Daily Dose for evaluation of bronchopneumonia pediatric antibiotics use at Roemani Muhammadiyah Hospital / Anatomical Therapeutic Chemical / Define Daily Dose antibiotik bronkopneumonia pediatri di RS Roemani Muhammadiyah

The increase in repeat hospitalizations after the covid19 pandemic with bronchopneumonia diagnoses in pediatric patients is the first rank. Therapeutic management was associated with the length of hospitalization. Pediatric bronchopneumonia is the case with antibiotic therapy. Current guidelines recommend first-line and alternative options in the management of antibiotic therapy for pneumonia in hospitalized pediatric patients. Empirical broad-spectrum antibiotic therapy for acute infections with consideration of the common etiology of possible pneumococcal involvement The risk of resistance increases with the massive use of antibiotics. The study had an observational descriptive design with retrospective data collection from 280 samples of pediatric patients, aiming to evaluate the use of antibiotics with the ATC/DDD method. Based on empirical selected therapy DDD (Define Daily Dose)/100 patient days, the quantity of antibiotics that are widely used is ceftriaxon 38.36 DDD /100 patient days followed by Cefoperazon sulbactam 3.88 DDD /100 patient days, Cefotaxime 3.77 DDD /100 patient days, Gentamicin 2.57 DDD /100 patient days, Amikacin 1. 70 DDD /100 patient days, Azithromycin 0.76 DDD /100 patient days, Ampicillin Sulbactam 0.50 DDD /100 patient days, Cefixime 0.27 DDD /100 patient days, and Meropenem 0.13 DDD /100 patient days. Drug data included in DU90% are Ceftriaxon, Cefoperzon Sulbactam, Cefotaxime. From the research conducted, the highest DDD/100 patient days value was Ceftriaxon. DDD value indicates high use of antibiotics, does not mean unreasonable use of drugs, so a qualitative review must be done.

Peningkatan kasus rawat inap berulang setelah pandemi covid19 dengan diagnosa bronkopneumonia pediatri menjadi peringkat pertama. Pedoman merekomendasikan pilihan lini pertama dan alternatif dalam pengelolaan terapi antibiotik untuk pneumonia pada pasien anak yang dirawat di rumah sakit. Terapi antibiotik spektrum luas empiris untuk infeksi akut dengan pertimbangan etiologi umum kemungkinan terjadinya resistensi meningkat seiring dengan penggunaan antibiotik yang masif. Penelitian deskriptif observasional dengan pengambilan data retrospektif dari 280 sampel pasien pediatri, bertujuan untuk mengevaluasi penggunaan antibiotik dengan metode ATC/DDD. Berdasar terapi pilihan bersifat empiris DDD (Define Daily Dose)/100 patient days kuantitas antibiotik yang digunakan yaitu ceftriaxon 38,36 DDD /100 patient days dilanjutkan dengan Cefoperazon sulbaktam 3,88 DDD /100 patient days, Cefotaxime 3,77 DDD /100 patient days, Gentamisin 2,57 DDD /100 patient days, Amikasin 1.70 DDD /100 patient days, Azitromisin 0,76 DDD/100 patient days, Ampisillin Sulbaktam 0.50 DDD /100 patient days, Cefixime 0,27 DDD /100 patient days, dan Meropenem 0,13 DDD /100 patient days. Data obat DU90% yaitu Ceftriaxon, Cefoperzon Sulbaktam, Cefotaxime. Berdasarkan penelitian yang dilakukan nilai DDD/100 patient days tertinggi adalah Ceftriaxon. Nilai DDD menunjukan penggunaan antibiotik yang tinggi, tidak berarti penggunaan obat yang tidak wajar, sehingga harus dilakukan tinjauan kualitatif.