Antidiabetic effect of GEMAR (Germinated Black Rice) beverage on diabetes mellitus model rats / Efek antidiabetes minuman GEMAR (Germinated Black Rice) pada tikus model diabetes melitus

Type 2 diabetes mellitus (T2DM) is a degenerative disease caused by increased blood glucose levels. Therapeutic recommendations for treating T2DM are the implementation of healthy lifestyle and pharmacological interventions. Germinated Black Rice contain high levels of fiber, anthocyanins and flavonoids. Functional beverage products Germinated Black Rice (GEMAR) is expected to help improve blood glucose levels and body weight in T2DM sufferers. This study aims to analyze the effect of beverage GEMAR at doses of 3.8 and 7.6 g/200 gBW on fasting blood glucose and body weight in T2DM rats. Laboratory experimental research method with design pre-posttest control group design. Samples of 30 male Wistar rats were divided into 5 groups. The results of the study found that the fasting blood glucose (GDP) of the acarbose drug group, P1 (GEMAR 3.8 g/200 g BW) and P2 (GEMAR 7.6 g/200 g BW) were significantly different (p<0.001) compared to the negative control group. GDP reducing effect of acarbose drug treatment (148%), P1 (177%), and P2 (128%). Body weight in the acarbose, P1 and P2 drug groups were significantly different (p<0.001) compared to the negative control. The improved effect of the drug groups acarbose (4%), P1 (7%), and P2 (5%) compared with adaptation. This research concludes that GEMAR P1 and P2 functional beverage can reduce GDP levels and improve body weight T2DM rats.

Diabetes melitus tipe 2 (DMT2) adalah penyakit degeneratif diakibatkan peningkatan kadar glukosa darah. Rekomendasi terapi untuk penanganan DMT2 adalah penerapan pola hidup sehat dan intervensi farmakologis. Kecambah beras hitam memiliki kandungan serat, antosianin, dan flavonoid tinggi. Produk minuman fungsional Germinated Black Rice (GEMAR) diharapkan membantu memperbaiki kadar glukosa darah dan berat badan penderita DMT2. Penelitian ini bertujuan menganalisis pengaruh minuman GEMAR dosis 3,8 dan 7,6 g/200 gBB terhadap glukosa darah puasa dan berat badan tikus model DMT2. Metode penelitian eksperimen laboratorik dengan rancangan pre-posttest control group design. Sampel tikus jantan sejumlah 30 ekor, terbagi menjadi 5 kelompok.  Hasil penelitian menemukan glukosa darah puasa (GDP) kelompok obat acarbose, P1 (GEMAR 3,8 g/200 g BB) dan P2 (GEMAR 7,6 g/200 gBB) signifikan berbeda nyata (p<0,001) dibandingkan kelompok kontrol negatif. Efek penurunan GDP dari perlakuan obat acarbose (148%), P1 (177%), dan P2 (128%). Perubahan berat badan pada kelompok obat acarbose, P1 dan P2 signifikan berbeda nyata (p<0,001) dibandingkan kontrol negatif. Efek perbaikan peningkatan kelompok obat acarbose (4%), P1 (7%), dan P2 (5%) dibandingkan saat adaptasi. Penelitian ini menyimpulkan minuman fungsional GEMAR P1 dan P2 dapat menurunkan kadar GDP dan memperbaiki peningkatan berat badan tikus model DMT2.