Activity of Noni Leaf Extract Gel (Morinda citrifolia) Against The Growth of Acne Causing Staphylococcus epidermidis Bacteria / Aktivitas Gel Ekstrak Daun Mengkudu (Morinda citrifolia) Terhadap Pertumbuhan Bakteri Penyebab Jerawat Staphylococcus epidermidis

Noni (Morinda citrifolia L.) is a plant that contains several chemistry compounds including flavanoids, saponins, tannin, Polyphenols and terpenoids as an antibacterial. The purpose of this study was to determine the ethanolic extract of noni (Morinda citrifolia L.) can be formulated into antibacterial gel preparations and inhibit the growth of Staphylococcus epidermidis bacteria and to determine the concentration of ethanolic extract of noni (Morinda citrifolia L.) can inhibit growth of Staphylococcus epidermidis bacteria. This research was conducted experimentally with evaluation of gel preparations and testing of antibacterial activity against concentration of 10 mg/ml, 15 mg/ml, 20 mg/ml, 25 mg/ml, 30 mg/ml, positive control, and negative control. The research results on the evaluation gel preparation with concentration of 10 mg/ml, 15 mg/ml, 20 mg/ml, 25 mg/ml, 30 mg/ml meet the gel preparation requirements as well as antibacterial acitivity tests, namely Staphylococcus epidermidis with a concentration of 10 mg/ml inhibiton zone 8 mm (weak), 15 mg/ml inhibiton zone 10,9 mm (medium), 20 mg/ml inhibition zone 16,75 (strong), 25 mg/ml inhibiton zone 12,1 mm (medium), and 30 mg/ ml inhibition zone 13,4 mm (medium). Conclusion : it was concluded that for a concentration of 20mg/ml with the highest diameter of the inhibition zone against Staphylococcus epidermidis bacteria

Mengkudu (Morinda citrifolia L.) merupakan tanaman yang mengandung berbagai senyawa kimia antara lain flavanoid, saponin, tanin, polifenol dan terpenoid sebagai anti bakteri. Tujuan penelitian ini adalah untuk mengetahui ekstrak etanol daun mengkudu (Morinda citrifolia L.) dapat diformulasikan menjadi sediaan gel antibakteri dan menghambat pertumbuhan bakteri Staphylococcus epidermidis, serta mengetahui konsentrasi berapa ekstrak etanol daun mengkudu (Morinda citrifolia L.) dapat menghambat pertumbuhan bakteri Staphylococcus epidermidis. Penelitian ini dilakukan secara eksperimental dengan evaluasi sediaan gel serta pengujian aktivitas antibakteri terhadap konsentrasi 10 mg/ml, 15 mg/ml, 20 mg/ml, 25 mg/ml, 30 mg/ml, kontrol positif, dan kontrol negatif. Hasil penelitian pada evaluasi sediaan gel dengan konsentrasi 10 mg/ml, 15 mg/ml, 20 mg/ml, 25 mg/ml, 30 mg/ml memenuhi syarat sediaan gel  serta uji aktivitas antibakteri yaitu Staphylococcus epidermidis dengan konsentrasi 10 mg/ml zona hambatnya 8 mm (Lemah),15 mg/ml zona hambat 10,9 mm (Sedang), 20 mg/ml zona hambat 16,75 mm (Kuat), 25 mg/ml zona hambat 12,1 mm (Sedang) dan 30 mg/ml  zona hambat 13,4 mm (Sedang). Kesimpulan : Disimpulkan bahwa pada konsentrasi 20 mg/ml dengan diameter zona hambat paling tinggi terhadap bakteri Staphylococcus epidermidis