Testing the effectiveness of senggani (Melastoma malabathricum L.) leaf ethanol extract as antihypertension in male white mouse (Mus musculus) / Uji efektivitas ekstrak etanol daun senggani (Melastoma malabathricum L.) sebagai antihipertensi pada mencit putih jantan (Mus musculus)

Background; Senggani leaves have secondary metabolites that can inhibit the release of aldosterone so that more water is removed from the body and blood pressure will drop. Objectives; The purpose of this study was to determine the effectiveness of the ethanol extract of senggani leaves (Melastoma malabathricum L.) on reducing blood pressure of male white mice (Mus musculus). Method; this research is experimental which includes sampling, sample processing, extract making, simplicia characteristics, preparation of test materials, treatment of test animals and data analysis. The samples used were senggani leaves (Melastoma malabathircum L.). The test animals used were 15 male white mice then divided into 5 groups. Measurement of blood pressure using a blood pressure analyzer with the tail cuff method. The measurement data were then analyzed using a paired t-test with a significance limit of 0.05. Result; showed that the ethanol extract of senggani leaves had antihypertensive effectiveness with the lowest systolic blood pressure measurement results after treatment at EEDS 150 mg/kgBW which was 86.66 mmHg and diastolic blood pressure obtained the lowest after treatment at EEDS 150 mg/KgBW, which was 59 mmHg. . The results of the statistical paired t-test showed that there was an effect of giving the test material EEDS 50 mg/kgBW, EEDS 100 mg/kgBW, EEDS 150 mg/kgBW test for 14 days with p-value <0.05. On diastolic blood pressure, the effect of treatment with the test material on blood pressure was significant at EEDS 150 mg/kgBW with p-value = 0.001. Conclusion; this study was that the administration of the ethanol extract of the leaves of senggani (Melastoma malabathricum L.) could reduce the blood pressure of experimental male mice (Mus musculus). The ethanol extract of senggani leaves (Melastoma malabathricum L.) was effective in lowering blood pressure at a dose of 150 mg.

Pendahuluan; daun senggani memiliki senyawa metabolit sekunder yang dapat menghambat pengeluaran aldosteron sehingga lebih banyak air dikeluarkan dari tubuh dan tekanan darah akan turun. Tujuan; untuk mengetahui efektivitas ekstrak etanol daun senggani (Melastoma malabathricum L.) terhadap penurunan tekanan darah mencit putih jantan (Mus musculus). Metode; eksperimental yang meliputi pengambilan sampel, pengolahan sampel, pembuatan ekstrak, karakteristik simplisia, penyiapan bahan uji, perlakuan terhadap hewan uji dan analisa data. Sampel yang digunakan yaitu daun senggani (Melastoma malabathircum L.) Hewan uji yang digunakan adalah 15 ekor mencit putih jantan kemudian dibagi menjadi 5 kelompok. Pengukuran tekanan darah menggunakan alat blood presure analyzer dengan etode tail cuff. Data hasil pengukuran kemudian dianalsis menggunakan uji paired t-test dengan batas kemaknaan 0,05. Hasil; ekstrak etanol daun senggani memiliki efektivitas antihipertensi dengan hasil pengukuran tekanan darah sistol paling rendah setelah perlakuan pada EEDS 150 mg/kgBB yaitu 86,66 mmHg dan diastol diperoleh tekanan darah paling rendah setelah perlakuan pada EEDS 150 mg/KgBB yaitu 59 mmHg. Hasil uji statistik paired t-test diperoleh adanya pengaruh pemberian bahan uji EEDS 50 mg/kgBB, EEDS 100 mg/kgBB, EEDS 150 mg/kgBB uji selama 14 hari dengan p-value < 0,05. Pada tekanan darah diastol pengaruh perlakuan pemberian bahan uji terhadap tekanan darah yang signifikan terdapat pada EEDS 150 mg/kgBB dengan p-value = 0,001. Kesimpulan; Pemberian ekstrak etanol daun senggani (Melastoma malabathricum L.) dapat menurunkan tekanan darah hewan coba mencit jantan (Mus musculus). Ekstrak etanol daun senggani (Melastoma malabathricum L.) efektif dalam menurunkan tekanan darah pada dosis 150 mg.