Association Between Matrix Metalloproteinase-8 (MMP-8) Levels in Gingivitis Patients After Scaling and Root Planing Based on Gingival Index (GI) / Hubungan Kadar Matrix Metalloproteinase-8 (MMP-8) pada Pasien Gingivitis Setelah Tindakan Scaling dan Root Planing Berdasarkan Gingival Index (GI)

This study aims to analyze the relationship between the Gingival Index (GI) and the levels of Matrix Metalloproteinase-8 (MMP-8) in the saliva of gingivitis patients after Scaling and Root Planing (SRP). A total of 36 gingivitis patients aged 15-24 years who underwent SRP in Padang City were included in the study. GI was assessed using the WHO probe, and saliva samples were collected on day 7 after SRP using the unstimulated saliva method. MMP-8 levels in the saliva were analyzed using an ELISA kit. The results showed higher average MMP-8 levels in the moderate and severe gingivitis groups compared to the mild group, but with considerable individual variation. The Kruskal-Wallis test revealed that the difference in MMP-8 levels among GI categories was not statistically significant (p = 0.584). Although there was a trend of increasing levels, these results suggest that MMP-8 cannot be used as a sole determinant of gingivitis severity and is better utilized as a supportive biomarker when combined with other clinical parameters.

Penelitian ini bertujuan untuk menganalisis hubungan Gingival Index (GI) terhadap kadar Matriks Metaloproteinase-8 (MMP-8) pada saliva pasien gingivitis pasca Scaling Root Planing (SRP). Sebanyak 36 pasien gingivitis berusia 15-24 tahun yang menjalani SRP di Kota Padang menjadi sampel penelitian. Pemeriksaan GI dilakukan dengan menggunakan probe WHO, dan pengambilan sampel saliva dilakukan pada hari ke-7 pasca SRP menggunakan metode unstimulated saliva. Kadar MMP-8 dalam saliva dianalisis menggunakan ELISA kit Hasil penelitian menunjukkan rerata kadar MMP-8 yang lebih tinggi pada kelompok gingivitis sedang dan berat dibandingkan kelompok ringan, namun variasi antar individu sangat besar. Uji Kruskal-Wallis menunjukkan bahwa perbedaan kadar MMP-8 antar kategori GI tidak signifikan secara statistik (p = 0,584). Meskipun ada tren peningkatan, hasil ini menunjukkan bahwa MMP-8 tidak dapat digunakan sebagai penentu tunggal derajat keparahan gingivitis, dan lebih tepat digunakan sebagai biomarker pendukung yang dikombinasikan dengan parameter klinis lainnya.