Drug Related Problems (DRPs) in Hospitalized patient with Eye Diseases: a Retrospective Cross-Sectional Study Over Two Years / Drug Related Problems (DRPs) pada Pasien Mata Rawat Inap: Kajian Potong Lintang Retrospektif selama Dua Tahun

Drug-related problems (DRPs) in ophthalmic inpatients may compromise the effectiveness and safety of therapy. This study aimed to identify the characteristics of DRPs among inpatients with eye diseases at Hospital X Tangerang during September 2022–August 2024. A retrospective cross-sectional design was applied, involving 178 patients who met the inclusion criteria. DRPs were identified using the Pharmaceutical Care Network Europe (PCNE) classification version 9.1 through review of prescriptions, clinical data, and medication records. Descriptive analysis were used to determine the DRP occurrence. Results showed that most patients were aged 18–60 years (71.9%), female (55.1%), without comorbidities (82.0%), and received an average of 5 medications during hospitalization. Four DRP cases (2.2%) were identified, consisting of one case of treatment effectiveness (P1.2) 25% and three cases of drug safety problems (P2.1) 75%. The main causes were contraindicated drug use despite guideline adherence (C1.2) 50%, inappropriate drug combinations (C1.4) 25%, and patient non-adherence (C7.1) 25%. The low DRP incidence was likely related to the short hospitalization duration and the predominance of topical therapy with minimal systemic exposure. These findings highlight the important role of clinical pharmacists in therapy monitoring to prevent DRPs in ophthalmic inpatients.

Masalah terkait obat (drug related problems/DRPs) pada pasien mata rawat inap dapat memengaruhi efektivitas dan keamanan terapi. Penelitian ini bertujuan untuk mengidentifikasi karakteristik DRPs pada pasien mata rawat inap di RSU X Tangerang periode September 2022–Agustus 2024. Desain penelitian ini adalah retrospektif dengan pendekatan cross-sectional terhadap 178 pasien yang memenuhi kriteria inklusi. Identifikasi DRP dilakukan menggunakan klasifikasi Pharmaceutical Care Network Europe (PCNE) versi 9.1 melalui telaah resep, data klinis, dan catatan pengobatan. Analisis dilakukan secara deskriptif digunakan untuk menentukan kejadian DRP. Hasil menunjukkan bahwa sebagian besar pasien berusia 18–60 tahun (71,9%), perempuan (55,1%), tanpa komorbid (82,0%), dan menerima rata-rata lima obat selama perawatan. Terdapat empat kasus DRP (2,2%) yang terdiri atas satu kasus efektivitas terapi (P1.2) 25% dan tiga kasus keamanan obat (P2.1) 75%. Penyebab utama meliputi penggunaan obat dengan kontraindikasi meskipun sesuai pedoman (C1.2) 50%, kombinasi obat tidak tepat (C1.4) 25%, dan ketidakpatuhan pasien (C7.1) 25%. Rendahnya angka DRP kemungkinan disebabkan oleh durasi rawat inap singkat serta dominasi terapi topikal yang memiliki risiko efek sistemik rendah. Hasil ini menegaskan pentingnya peran apoteker klinis dalam pemantauan terapi untuk mencegah DRP pada pasien mata rawat inap.