Correlation Between Vitamin C, Cholecalciferol, and Malondialdehyde Levels in Abortus and Normal Pregnancy: An Observational Study / Korelasi Kadar Vitamin C, Cholecalciferol dan Kadar Malondialdehid Antara Kejadian Abortus Dengan Kehamilan Normal : Studi Observasional

Introduction: Abortion is a pregnancy complication that contributes significantly to maternal morbidity and mortality. Approximately 73 million abortions occur annually worldwide, with the estimated abortion rate in Padang city in 2024 reaching 58.7%. Abortion remains a challenge in obstetrics. The relationship between vitamin C deficiency, cholecalciferol, and elevated MDA levels and abortion remains debated, given the complex pathophysiological mechanisms. Objective: to determine the correlation between vitamin C, cholecalciferol, and malondialdehyde levels between abortion and normal pregnancy. Method: This study is a comparative study of two unpaired groups with a cross-sectional approach to analyze the average levels of Vitamin C, cholecalciferol, and MDA. The population in this study was pregnant women diagnosed with abortion and all women with normal pregnancies with a gestational age of ≤ 20 weeks who were treated in the delivery room of RSUD dr. M. Zein, RS. dr. Reksodiwiryo Padang, RSUP M. Djamil Padang, RS. Rasidin Padang with a sample size of 30. Data analysis was carried out using an Independent Samples T-test. Results: The results of this study showed that Vitamin C levels were lower in the abortion group than in the control group, a significant difference (p = 0.001). Cholecalciferol deficiency was more pronounced in the abortion group, a significant difference compared to normal pregnancies (p = 0.002). MDA levels were very high in the abortion group, a significant difference (p = 0.001). Conclusion: There is a significant correlation of Vitamin C and cholecalciferol levels between the occurrence of abortion and normal pregnancy, and there is a significant correlation of malondialdehyde levels between normal pregnancy and the occurrence of abortion.

Pendahuluan: Abortus merupakan komplikasi kehamilan yang berkontribusi paling tinggi terhadap angka morbiditas dan mortalitas maternal. Sekitar 73 juta abortus terjadi setiap tahunnya diseluruh dunia, angka kejadian abortus di kota Padang pada tahun 2024 yaitu 58,7%. Abortus hingga saat ini masih menjadi tantangan dalam dunia kebidanan. Hubungan antara defisiensi Vitamin C, cholecalciferol dan serta peningkatan kadar MDA. Tujuan: untuk mengetahui korelasi kadar vitamin C, Cholecalciferol dan Kadar Malondialdehid antara kejadian abortus dengan kehamilan normal. Metode: Penelitian ini merupakan penelitian Komparatif dua kelompok tidak berpasangan dengan pendekatan cross sectional untuk menganalisis rerata kadar Vitamin C, cholecalciferol dan MDA pada ibu abortus dan kehamilan normal. Populasi pada penelitian ini adalah ibu hamil dengan diagnosa abortus dan seluruh wanita dengan kehamilan normal dengan usia kehamilan ≤ 20 minggu yang dirawat di dikamar bersalin RSUD dr. M. Zein, RS. dr. Reksodiwiryo Padang, RSUP M. Djamil Padang, RS. Rasidin Padang dengan jumlah sampel 30 sampel. Analisis data dengan uji Independent Sampel T Test. Hasil: Hasil penelitian ini menunjukan rerata kadar Tingkat vitamin C lebih rendah pada aborsi dibandingkan dengan kelompok kontrol, perbedaan yang signifikan (p = 0.001). Defisiensi cholecalciferol lebih menonjol pada aborsi, perbedaan yang signifikan dibandingkan dengan kehamilan normal (p = 0.002). Tingkat MDA sangat tinggi pada kelompok aborsi, perbedaan yang signifikan (p = 0.001). Kesimpulan: Terdapat korelasi yang signifikan kadar Vitamin C dan cholecalciferol antara kejadian abortus dan hamil normal dan terdapat korelasi kadar malondialdehid antara hamil normal dan kejadian abortus.