Effervescent Granule Formulation Containing Cyclea barbata Miers Leaf Extract: Physical Evaluation (Before and After Reconstitution) / Formulasi Granul Effervescent Mengandung Ekstrak Daun Cyclea barbata Miers: Evaluasi Fisik (Sebelum dan Sesudah Rekonstitusi)

Cyclea barbata Miers leaf extract contains flavonoid compounds that have anti-inflammatory activity. This study aims to determine the effect of variations in citric acid and sodium bicarbonate concentrations on the physical properties of effervescent granules before (organoleptic, flow time, angle of repose, water content, and compressibility index test) and after (organoleptic, dissolve time, foam height, pH, and hedonic) reconstitution. Effervescent granules were formulated using the wet granulation method using varying concentrations of citric acid: sodium bicarbonate, respectively, it is FI (17%: 30%), FII (20%: 27%) and FIII (23%: 24%). Based on the results of the evaluation test of the physical properties of effervescent granules, FI and FII are appropriate for the requirements of each test, while FIII did not appropriate the requirements in the flow time, angle of repose, foam height and pH tests. This study concludes that FI (17%:30%) demonstrated the most optimal physical properties, meeting all evaluation parameters and receiving the highest hedonic score.

Ekstrak daun Cyclea barbata Miers mengandung senyawa flavonoid yang mempunyai aktivitas antiinflamasi. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi asam sitrat dan natrium bikarbonat terhadap sifat fisik granul effervescent sebelum (uji organoleptik, waktu alir, sudut diam, kadar air, dan indeks kompresibilitas) dan setelah (uji organoleptik, waktu larut, tinggi busa, pH, dan hedonik) rekonstitusi. Granul effervescent diformulasikan menggunakan metode granulasi basah dengan variasi konsentrasi asam sitrat: natrium bikarbonat berturut-turut yaitu FI (17%:30%), FII (20%:27%) dan FIII (23%:24%). Berdasarkan hasil uji evaluasi sifat fisik granul effervescent, FI dan FII sesuai dengan persyaratan masing-masing pengujian, sedangkan FIII tidak sesuai dengan persyaratan pada uji waktu alir, sudut diam, tinggi busa dan pH. Studi ini menyimpulkan bahwa FI adalah formula terbaik (17%: 30%).