Effectiveness of Healing Second Degree Burns Gel Preparation of bilimbi Extract (Averroa bilimbi L.) Against Male Wistar Rats / Efektivitas Penyembuhan Luka Bakar Derajat II Sediaan Gel Ektrak Buah Belimbing Wuluh (Averroa bilimbi L.) Terhadap Tikus Jantan Galur Wistar

Burns are lesions on body tissues that occur due to exposure to heat sources such as fire, chemicals, or electric currents. Bilimbi (Averroa bilimbi L.) is thought to have therapeutic properties to treat burns in male Wistar rats. Burn healing is divided into 3 phases of inflammation, proliferation, and maturation. This study was to prove the ability of the ethanol extract gel preparation of bilimbi in the process of healing burns. Bilimbi extract gel was formulated in three concentration variations, namely 2.5%, 5%, and 10%. Control testing of the preparation included organoleptic, homogeneity, spreadability, viscosity, and adhesion. The bilimbi extract gel preparation with a series of concentrations of 2.5%, 5%, and 10% gave an effect in healing second-degree burns. The percentage data of burn diameter were analyzed using ANOVA. The results of statistical analysis showed that the preparation of ethanol extract gel from star fruit with a concentration of 10% gave a healing effect with a healing percentage of 86% which was almost the same as the positive control. This healing effect is thought to come from the content of star fruit such as alkaloids, flavonoids, saponins.

Luka bakar merupakan lesi pada jaringan tubuh yang terjadi akibat paparan sumber panas api, zat kimia, atau arus listrik. Buah belimbing wuluh (Averroa bilimbi L.) diduga memiliki kemampuan terapetik untuk mengobati luka bakar pada tikus jantan galur wistar. Proses penyembuhan luka bakar dibagi menjadi 3 fase peradangan, poliferasi dan pematangan. Penelitian ini untuk membuktikan kemampuan sediaan gel ekstrak etanol buah belimbing wuluh dalam proses  penyembuhan luka bakar. Gel ekstrak buah belimbing wuluh diformulasikan dalam tiga variasi kosentrasi yaitu 2,5%, 5% dan 10%. Pengujian kontrol sediaan meliputi organoleptis, homogenitas, daya sebar, viskositas, dan daya lekat. Sediaan gel ekstrak buah belimbing wuluh dengan seri konsentrasi 2,5%, 5% dan 10% memberikan efek pada penyembuhan luka bakar derajat II. Data persentase diameter luka bakar dianalisis menggunakan ANOVA. Hasil analisis statistik menunjukkan bahwa sediaan gel ekstrak etanol dari buah belimbing wuluh dengan kosentrasi 10% memberikan efek penyembuhan persentase penyembuhan sebesar 86% yang hampir sama dengan kontrol positif. Efek penyembuhan ini diduga berasal dari kandungan buah belimbing wuluh seperti alkaloid, flavonoid, saponin.