The qualitative and quantitative analysis are critical parameters in quality control to ensure the efficacy, safety and quality of a drug. Cimetidine is a drug that is widely used in the treatment of peptic ulcers. The molecular structure of cimetidine has a chromophore group and an auxochrome group which allows for ultraviolet spectrophotometric analysis. The purpose of this study is to develop, validate, and apply a simple and fast ultraviolet spectrophotometric method in qualitative and quantitative analysis of cimetidine compounds in tablet preparations on the market, both preparations with generic names and preparations with trade names. The solvents used were hydrochloric acid solution 0.1 N as acidic solvent and sodium hydroxide solution 0.1 N as basic solvent. The results showed that qualitative and quantitative analysis of the cimetidine compound by ultraviolet spectrophotometry both with acidic solvent and basic solvent can be applied for routine analysis and has good validity. The qualitative and quantitative analysis of cimetidine tablet preparations in circulation were also successfully applied and met the requirements of the cimetidine tablet monograph in Indonesian Pharmacopoeia, 6th edition, year 2020.